The patients' heterogeneous responses to TPO mimetic treatment.ġ. Will be of equal importance and interest to investigate the molecular mechanisms underlying Response to treatment will be useful in reducing both cost and potential side effects and it The identification of predictive blood biomarkers of patients' Treatment-resistant patients are un-characterized and the reasons for the lack of response Great majority of patients with chronic ITP in several clinical trials.1, 2 Nevertheless,Ībout 20% of patients with ITP fail to respond to the TPO mimetic treatment. Thrombopoietin (TPO) mimetics have shown good efficacy in boosting platelet counts in the Thrombocytopenia (ITP) in addition to increased platelet destruction. Ineffective platelet production has been proven to play a role in the etiology of Immune
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